Researchers identify a novel source of adult stem cells: Foreign body-induced granulation tissue

Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} In a pioneering new study published in the journal TranslationalResearch , Dr. Jilpa Patel and her research group at HektoenInstitute of Medicine and Cook County Hospital in Chicago have isolated and characterizedadult stem cells from granulation tissue in rats. A granulation tissue is a newregenerating tissue formed in response to an inert foreign body placed in thesubcutaneous tissue. This is the first time a study has shown that such aregenerating granulation tissue is replete with stem cells, which are rich ingrowth factors. These stem cells called granulation-tissue stem cells (GTSC)can be easily obtained, and multiplied infinitely outside the body to get largenumber of stem cells. GTSC are ‘pluripotent’ stem cells meaning they arecapable of becoming many different cell types like bone, cartilage and fatcells under the right conditions. When injected into the body with an injuredorgan, GTSC engraft only to the injured organ and not a to normal organ, whichshows that these stem cells have the propensity to recognize and reach injuredorgans in the body. This is vital since it would now be possible to give aperipheral (intravenous) injection of these stem cells for treatment of organdamage. Another important finding reported in this study is that GTSC can befrozen for long-term storage without loss of potency. According to Dr. Patel, GTSC can serve as anexcellent source of stem cells for the treatment of damaged organs because theyare pluripotent stem cells that can be easily obtained from the patient’s ownbody, multiplied infinitely outside the body, and can be stored long-term. Stem cells are cells that have the ability to renewthemselves continuously as well as differentiate togive rise to diverse cell types. Stem cellsare by and large categorized as either a) embryonic stem cells, that areobtained from the inner cell mass of an embryo or b) adult stem cells, thosethat are derived from adult tissues. The use of embryonic stem cells iscontroversial as it is hampered by ethical, political and safety concerns. Incontrast, adult tissue derived stem cells (bone marrow cells being thecommonest of adult stem cells) are free of such concerns and therefore hold tremendous potential for their usein human medicine. Adult stem cells have been isolated from many tissueincluding bone marrow, adipose tissue, skin, hair, dental pulp, and omentum.Because granulation tissue derived stem cells (GTSC) described by Dr. JilpaPatel in this study are obtained from a rapidly regenerating granulationtissue, they are activated stem cells, and therefore they could prove to bemore potent than other adult tissue-derived stem cells.   Indeed in the preliminary studies conductedby the authors to assess the utility of GTSC they have found incredible resultsfor the treatment of kidney disease and osteoarthritis and further studies are ongoing. Inconclusion, the authors of this study have shown that a regenerating granulationtissue is an abundant and unique source of adult stem cells, which could beused for repair and regeneration of damaged organs . Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Source: Translational Research , doi: 10.1016/j.trsl.2009.08.010 Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}

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You're reading Researchers identify a novel source of adult stem cells: Foreign body-induced granulation tissue.